All guides

• Does Ozempic cause muscle loss? What the STEP 1 scans showed

  Semaglutide lowers lean mass along with fat, as any large weight loss does. In the STEP 1 body-scan substudy (n = 140, DXA), lean mass made up about 40% of the tissue lost, though lean mass includes water and organs, not only muscle. If you are worried, ask your prescriber about strength training and protein.

• How much protein should you eat on a GLP-1?

  A 2025 advisory from four US nutrition and obesity societies says targets of 1.2 to 1.6 grams of protein per kilogram a day have been proposed during active weight loss, or a flat 80 to 120 grams. If you have kidney disease, ask your clinician first; otherwise use that range and split it across meals.